The quality control machinery regulates the cellular proteome to ensure proper protein homeostasis (proteostasis).In Caenorhabditis elegans, quality control networks are downregulated cell-nonautonomously by the gonadal longevity pathway or metabolic signaling at the onset of reproduction.However, how signals are HONEYDEW CONDITIONER mediated between the gonad and the somatic tissues is not known.Gonadotropin-releasing hormone (GnRH)-like signaling functions in the interplay between development and reproduction and have conserved roles in regulating reproduction, metabolism, and stress.We, therefore, asked whether GnRH-like signaling is involved in proteostasis collapse at the onset of reproduction.
Here, we examine whether C.elegans orthologues of GnRH receptors modulate heat shock survival.We find that gnrr-2 is required for proteostasis remodeling in different somatic tissues during the transition to adulthood.We show that gnrr-2 likely functions in neurons downstream of the gonad in the gonadal-longevity pathway and modulate the somatic regulation of transcription factors HSF-1, DAF-16, and PQM-1.In parallel, gnrr-2 modulates egg-laying Armless Chair rates, vitellogenin production, and thus reproductive capacity.
Taken together, our data suggest that gnrr-2 plays a GnRH-associated role, mediating the cross-talk between the reproduction system and the soma in the decision to commit to reproduction.