The quality control machinery regulates the cellular proteome to ensure proper protein homeostasis (proteostasis).In Caenorhabditis elegans, quality control networks are downregulated cell-nonautonomously by the gonadal longevity pathway or metabolic signaling at the onset of reproduction.However, how signals are HONEYDEW CONDITIONER mediated betwe
Investigating functional brain network integrity using a traditional and novel categorical scheme for neurodevelopmental disorders
Background: Current diagnostic systems for neurodevelopmental disorders do not have clear links to underlying neurobiology, limiting their utility in identifying targeted treatments for individuals.Here, we aimed to investigate differences in functional brain network integrity between traditional diagnostic categories (autism spectrum disorder [ASD
A Psychometric Perspective on the Associations between Response Accuracy and Response Time Residuals
We provide an alternative psychometric perspective on the empirical statistical dependencies observed between response accuracy residuals (RARs) and response time residuals (RTRs) in the context of the van der Linden model.This perspective emphasizes the RAR (or parts of the RAR) as being exogenous and having a directional influence on response tim